Endocrine Abstracts

Rare cases of Cushing’s syndrome have been diagnosed only based upon bone manifestations. Fracture risk is related to individual susceptibility to glucocorticoids that is genetically determined by several factors, including VDR gene polymorphism.We report three patients with VDR FokI gene polymorphism and multiple non-traumatic pathologic fractures as the presenting manifestation of Cushing’s syndrome.The second case is a...

Introduction: Solid cell nests (SCNs) of the thyroid are considered embryological remnants of the ultimobranchial bodies and the thyroid diverticulum. They are frequently (61–89%) detected in the thyroid gland, but their biological significance remains disputable. According to the fetal cell thyroid carcinogenesis hypothesis SCNs may act as a source for specific thyroid cancer stem cells generating distinct thyroid cancer phenotypes. We report a case of a patient with con...

Introduction: Adrenal crisis due to primary adrenal insufficiency may result in severe morbidity and mortality if undiagnosed or ineffectively treated. Main manifestations are hypotension (>90%), hyponatremia (70–80%), and hyperkalemia (30–40%), while hypoglycemia is rare. An unusual case of a septic patient with hypokalemia and hypomagnesemia with hypoglycemic coma as first manifestation of acute adrenal insufficiency is presented.Case pre...